SLAM Family Receptors and SAP Adaptors in Immunity (Annual Review of Immunology Book 29) Pdf

SLAM Family Receptors and SAP Adaptors in Immunity (Annual Review of Immunology Book 29) Pdf
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The signaling lymphocyte activation molecule (SLAM)-associated protein, SAP, was first acknowledged as a result of the protein affected in most situations of X-linked lymphoproliferative (XLP) syndrome, a unusual genetic dysfunction characterised by irregular responses to Epstein-Barr virus an an infection, lymphoproliferative syndromes, and dysgammaglobulinemia. SAP consists nearly completely of a single SH2 protein space that interacts with the cytoplasmic tail of SLAM and related receptors, along with 2B4, Ly108, CD84, Ly9, and in all probability CRACC. SLAM relations in the mean time are acknowledged as mandatory immunomodulatory receptors with roles in cytotoxicity, humoral immunity, autoimmunity, cell survival, lymphocyte enchancment, and cell adhesion. On this evaluation, we cowl present findings on the roles of SLAM family receptors and the SAP family of adaptors, with a think about their regulation of the pathways involved in the pathogenesis of XLP and totally different immune points.

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