Pathological coronary coronary heart rhythms are a critical nicely being concern. On this book specialists from quite a few fields current an essential context for understanding the troublesome molecular and cellular mechanisms that underlie common and pathophysiological cardiac rhythms.
Specific individual chapters cowl a full differ of topics, along with the ionic basis of pacemaking, the place of specific channels and transporters in sinoatrial node pacemaking, altered intracellular Ca2+ coping with in response to sickness, laptop modeling of the movement potentials of pacemaker and working cardiomyocytes, genetic and molecular basis of inherited arrhythmias and a analysis of established and novel antiarrhythmic brokers. Due to the important thing significance of the specialised pacemaker cells and tissue (sinoatrial and atrioventricular nodes) in sustaining coronary coronary heart worth and rhythm, specific emphasis is positioned on the peculiar electrophysiology of these cells.
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